camptothecin相关论文
Near-infrared light triggered ROS-activated theranostic nanoparticles for orthotopic lung tumors ima
Many drug control release regulated have been utilized in nanoparticles,such as pH-,redox-,temperature-,enzyme-,and ligh......
Camptothecin-conjugated biodegradable prodrug micelles for theranostic near-infrared fluorescent ima
Camptothecin(CPT) has shown significant antitumor activity in a broad spectrum of human malignancies.However,its use is ......
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing Topotecan as ortho-Quinone Methide P
Camptothecin(CPT)is a pentacyclic alkaloid that was isolated by Wall and Wani from Camptotheca acuminate in 1966,and sho......
Azadirachtin and camptothecin induce mitochondria-mediated apoptosis by influencing of calcium homeo
Calcium homeostasis plays an important role in apoptosis of mammal and insect cells.However, there are only a few report......
Continuing our search for natural product-based spin-labeled antitumor drugs,a series of novel spin-labeled camptothecin......
Anti-cancer effects of PLGA microspheres containing anti-cancer drug dispersed in thermoreversible g
Purpose: The effect of anti-cancer drug against brain tumor is not enough and glioma usually has a poor outcome.In this ......
Study of two camptothecins binding to calf thymus DNA by spectroscopic techniques and molecular dock
Camptothecin is a hydrophobic plant alkaloid isolated from Camptotheca acuminate,which has been demonstrated to be an ef......
A simple route to a novel acid sensitive 20 (S)-O-linked camptothecin norcantharidine acid ester der
a facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidine acid ester derivative Ⅰ......
Acidic Leucine-rich Nuclear Phosphoprotein 32B, a New Apoptosis Modulator Revealed by Subccllular Pr
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Density function M06 method has been used to optimize the geometries of camptothecin-cytosine at 6-31+G* basis.Finally, ......
A series of new 3-benzoheterocyclic substituted pyridopyrimidines were designed and synthesized.Structures of the compou......
The electron impact mass spectrometric behavior of ten camptothecin analogs(1—10)is described and discussed in detail ......
Induction of apoptosis in human T leukemic cell line CEM-6T by tripter-ine;comparison with arsenic o
In China, the herbal plant Lei gong teng (tryipterygium wolfordii Hook F) is widely used in rheumatic diseases, indicati......
A novel camptothecin analogue,9-methyl-10-hydroxycamptothecin(4),was unexpectedly synthesized from 10-hydroxycamp- tothe......
目的 探讨羟喜树碱(HCPT)对胃癌细胞的致凋亡作用及其相关作用机制.方法 MTT细胞毒性试验检测HCPT对人胃癌SGC-7901细胞的生长抑制......
HPLC analysis of camptothecin content in various parts of Nothapodytes foetida collected on differen
Objective:To investigate the content of topoisomerase I-DNA inhibitor alkaloid camptothecin(CPT) from various parts of N......
利用HPLC技术在日本蛇根草中检测到了抗癌药物喜树碱(CPT)和羟基喜树碱(HCPT),而这2种药物是当今世界应用比较广泛的抗癌药物.蛇根......
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ObjectivesToelucidatetherapeuticmechanismoftopticalcamptothecin (CPT) intreatingpsoriasisandtodetecttheefectsofCPTo......
Recently, many reports showed that most of cytotoxic anticancer drugs in current usesuch as DNA topoisomerase Ⅰinhibit......
Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard ......
Aim:To build up a quantitative structure-activity relationship(QSAR)model of20(S)-camptothecin(CPT)analogs for the pred......
Preparation and characterization of inclusion complexes of antitumor camptothecin with cucurbit[n=7,
The slightly water-soluble anticancer drug camptothecin(CPT) and its inclusion complexes with cucurbit[n = 7,8]uril(Q[n]......
To improve the biological anticancer activity of 20(%S%)-camptothecin, a novel class of 20(%S%)-20-%O%-camptothecin %β%......
Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-38......
An Approach to New Water-soluble Oligo(ethylene glycol) Camptothecin Analogues by 1,3-Dipolar Cycloa
Combined with an effective copper-catalyzed triazole-forming reaction,a series of novel camptothecin derivatives were sy......
AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer com......
目的为了克服上市药物伊立替康酶转化率低、个体差异大以及由乙酰胆碱酯酶抑制作用而引发的毒副作用等不足,设计合成高效低毒的新......
目的用β-硫代酯键构建新型肿瘤靶向性喜树碱大分子前药以达到减毒增效的目的。方法首先用可控聚合和大分子改性的方法,得到新型肿......
Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a variety of tumors. SN-38 ......
Aim: To study the degrees of influence of changing side ester chains at position C20 of camptothecin on the anti-tumor a......
,Development and evaluation of lipid nanoparticles for camptothecin de-livery: a comparison of solid
Aim:Camptothecin is an anticancer drug that acta against a broad spectrum of tumors. The clinical application of camptot......
The conjugation of small molecular hydrophobic anticancer drugs onto a short peptide with overall hydrophilicity to crea......
,Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptot
We demonstrate a novel inorganic-organic crystalline nanoconstruct,where gold atoms were imbedded in the crystal lattice......
Camptotheca acuminata Decne Residue after Camptothecin Extract as a Substrate to Produce Mushroom Sp
Currently in China,no technically and economically viable methods exist to handle large quantities of Camptotheca acumin......
The effects of different nitrogen sources on camptothecin content and related gene expression in Cam
Camptotheac acuminata Decne is a unique tree species in China with an important secondary metabolite,camptothecin (CPT),......
[目的]建立HPLC测定马比木根中喜树碱含量的方法。[方法]HPLC法测定,色谱柱为Diamonsil C 18柱(5μm,250mm×4.6mm),流动相为乙腈:......
Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel a
The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already become very promising in cancer chemotherap......
喜树碱是从我国南方特有的植物喜树中分离出来的一种五环类生物碱,由于其在实验和临床研究中表现出的强大抗肿瘤效应,而引起临床医......
以喜树(Camptotheca acuminata)幼林为试验材料,在田间条件下施以不同剂量的氮素,测定了光合速率、叶绿素含量、喜树碱含量等的变......
栽培密度是植物生长的重要影响因子,能够显著影响植物的生长.2004年5月,将温室培养的喜树(Camptotheca acuminata Descne)幼苗按照......
Synthesis and Insecticidal Activity of Novel Camptothecin Derivatives Containing Analogs of Chrysant
C reating high-efficient and environment-friendly pesticides is very important to produce the pollution free agriculture......
目的研究9-甲基哌嗪甲基-10-羟基喜树碱氮氧化物(HCNO-YCS-03)对肺癌A549细胞体内、外抑制作用及乏氧选择性。方法采用MTT法和流式......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis of 7-Triazole-substituted Camptothecin via Click Chemistry and Evaluation of in vitro Anti
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast ca
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Visible-Light-Induced Radical Cascade Cyclization: Synthesis of (20S)-Camptothecin, SN-38 and Irinot
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cell
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
应用ABEEM/MM分子力场结合ABEEMσπ/GB/SA方法,分别研究了内酯和羧酸盐形式喜树碱以及不含内酯结构的S39625与Topl-DNA复合物相互......
